Hyperpigmentation: Causes, Treatments, and Medications That Can Trigger It
When your skin darkens in patches, it’s usually hyperpigmentation, a condition where excess melanin builds up in certain areas of the skin. Also known as skin discoloration, it’s not dangerous—but it can be frustrating, especially when it shows up on your face, hands, or other visible areas. This isn’t just about sun damage. Many common medications can cause or worsen it, often without warning.
Drug-induced hyperpigmentation, a side effect caused by certain medications that trigger melanin production is more common than most people realize. Antibiotics like minocycline, chemotherapy drugs, antimalarials, and even some antidepressants have been linked to dark spots on the skin. It’s not always obvious at first—you might notice a faint gray or brown tint after weeks or months of use. If you’re on any long-term medication and see new patches of darker skin, it’s worth checking with your doctor. The good news? Stopping the drug often helps, but sometimes the discoloration sticks around.
Other triggers include hormonal changes, acne scars, and prolonged sun exposure. Melanin, the natural pigment that gives skin its color is your body’s defense against UV rays—but too much of it, in the wrong places, leads to uneven tone. That’s why sunscreen isn’t optional if you’re dealing with hyperpigmentation. Even on cloudy days, UV light can make dark spots worse. Topical treatments like hydroquinone, retinoids, and vitamin C serums can help fade them over time, but results take patience. Some people turn to chemical peels or laser therapy, but these carry risks if not done right.
What you won’t find in most guides is how often hyperpigmentation is tied to something you’re taking—not just your skincare. The posts below dig into exactly that: how medications like statins, antibiotics, and even supplements can change your skin’s appearance. You’ll also find real advice on how to spot early signs, what to ask your pharmacist, and which treatments actually work without causing more problems. Whether you’re trying to fix dark spots from an old acne breakout or wondering if your new pill is to blame, you’ll find clear, no-fluff answers here—no marketing hype, just facts.
